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Tohoku University Technology: Urinary toxin reducer with sesamol: T20-695

Tohoku University Technology: Urinary toxin reducer with sesamol: T20-695

Sesamol inhibits enzymes produced by intestinal bacteria

Phenyl sulfate(PS) and indoxyl sulfuric(IS) are factor of Diabetic nephropathy(DN). These compounds are produced by the reaction of phenol and indole which are protein metabolites, with tyrosine phenol lyase and tryptophan indole lyase which intestinal bacteria have. Decreasing PS and IS in blood is important for DN treatment.　 　In the present study, certain sesame-derived lignans exhibited TPL and TIL inhibitory activity.

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Tohoku Univ. Technology : Intestinal bacteria that reduce uremic substances : T22-046

Tohoku Univ. Technology : Intestinal bacteria that reduce uremic substances : T22-046

Intestinal bacteria that reduce p-cresyl sulfate

Previous studies have shown that several uremic substances, which cause exacerbation of diabetic nephropathy, are produced by intestinal bacteria. On the other hand, identification of intestinal bacterial species involved in the production of uremic substances has been difficult due to confounding factors such as renal function. The inventors identified intestinal bacteria involved in the reduction of uremic substances by analyzing them without confounding factors of renal function. The present invention relates to an agent for inhibiting the production of uremic toxins and a functional food containing these bacteria. Sesamol has also been proposed as a functional ingredient for reducing uremic substances by Professor Abe et al., one of the present inventors. (Uremic substance reducing agent containing sesame lignan (ttechnoarch.co.jp)) It is expected that the bacteria of the present invention will not be used as a single agent but will be commercialized aiming at a synergistic effect by combining with the above functional ingredients.

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